Continuous-Flow Catalysis

Furrow geometry nnder surge and continuous flow

Continuous-flow homogeneous catalysis using the temperature-controlled solvent properties of supercritical carbon dioxide.

A fully integrated continuous process for homogeneous catalysed reactions in scCO(2) has been developed exploiting the tunable solvent properties of scCO(2). A heated condenser situated above the reaction zone leads to a phase split under isobaric conditions resulting in efficient catalyst retention and recirculation. Continuous isomerisation of allylic alcohols was carried out for over 200 hou...

Continuous API Synthesis using Heterogeneous Catalysis

The pharmaceutical industry currently experiences a trend towards continuous manufacturing as there are many advantages, including better control of process conditions, effectively eliminating batch-to-batch variability, and the lack of scale-up problems, since even bench-top continuous systems can produce the desired quantities required in the pharmaceutical or fine-chemicals industry. We pres...

Visible-light photoredox catalysis in flow.

Photoredox catalysts have recently been utilized as powerful tools for synthetic chemists to exploit the energy gained by the absorption of low-energy light within the visible spectrum to initiate a variety of organic transformations. The development of methods based on the single electron transfer properties of photoredox catalysts, particularly in the last several years, has represented a par...

Recent Advances in Asymmetric Catalysis in Flow

Asymmetric catalysis in flow has been attracting much attention very recently because of the potential advantages over its batchwise counterpart, such as highthroughput screening and synthesis, easy automation with the integration of on-demand reaction analysis, little or no reaction workup, and potential long-term use of the catalysts in the case of heterogeneous catalysis. Homogeneous asymmet...